lysosome相关论文
胆固醇是人类基本生命活动中的一类重要的甾醇类分子,由一个环戊烷多氢菲的甾核以及烷基侧链组成。胆固醇参与细胞膜的形成,同时也......
Programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) cascade is an effective therapeutic target......
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in
We have previously shown that roflupram (ROF) protects against MPP+-induced neuronal damage in models of Parkinson\'s ......
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EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise its effectiveness in lung ca
Objective Lung cancer is the most frequent cause of cancer-associated deaths worldwide,and NSCLC(non-small cell lung can......
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Background Heat shock factor 4,which is a regulator of heat shock response by upregulating the expression of heat shock ......
Microglia are highly motile cells that act as the main form of active immune defense in the central nervous system.Attra......
Objective Autophagy is a process which can be activated during various stress conditions.Our previous study reported tha......
The contribution of autophagy-lysosomal pathway to neuronal death and its underlying mechanisms in t
Objective To investigate activation of autophagy by permanent focal cerebral ischemia,the effects of blocking autophagy-......
Autophagy dysfunction is considered as a potential toxic mechanism of nanomaterials1.Silica nanoparticles(SiNPs) induced......
Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumin
Super-resolution optical microscopy has extended the scope of cell biology from the cellular level to the nanoscale,givi......
Chymotrypsin B:Not Just a Digestive Enzyme, But Involved in Oxidative Stress-Induced Apoptosis via a
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Lysosome, the cells recycling center, is required for the cells to eliminate waste materials and cellular debris.Recent ......
A lysosome-targeted and two-photon excitable iridium(Ⅲ)complex for bimodal visualization of endogeno
Nitric oxide(NO)is a fundamental signaling molecule that shows complex effects on the catabolic autophagy process,which ......
Dual Functions of Cyclometalated Iridium(Ⅲ)Complexes:Anti-metastasis and Lysosome-damaged Photodynam
Cancer metastasis and drug resistance lead to treatment difficulty and increasing mortality rates....
Fluorescent probes are powerful tools for biosensing and bioimaging due to their high sensitivity,specificity,rapid resp......
Many Phosphorescent iridium complexes potent candidates for photodynamic therapeutic agents....
Three lysosome-targetable fluorescence probes for sensitively and selectively monitoring subcellular
As the advanced organelles found in eukaryotic cells,lysosomes are considered crucial regulators of cell homeostasis.The......
Light-induced translocation of CPE in cells: polymer design, synthesis, and applications in cell ima
In our previous work,1 we synthesized PPET3-N2 and demonstrated its potential application in cell imaging.In the current......
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Many neurodegenerative diseases are characterized by abnormal accumulations of insoluble protein aggregates, such as......
γ-L-glutamyl-S-[2-[[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]carbonyl......
Caveolin-1 (CAV1) is well known as a principle scaffolding protein of caveolae, a specialized plasma membrane struct......
Autophagy helps deliver sequestered intracellular cargo to lysosomes for proteolytic degradation and thereby maintai......
应用电子显微镜观察了大鼠第２段近端肾小管溶酶体系统超微结构。用显微分光光度计对溶酶体标志酶酸性磷酸酶和芳香硫酸酯酶作了测定......
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals......
Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide
Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzhei-mer’s disease. The generation ......
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荷脂细胞胆固醇逆向转运(RCT)能力是决定动脉粥样硬化(AS)病程的关键。自噬促进RCT是其重要调控方式,然而在动脉粥样硬化中自噬的......
Background: High proliferative rate of cancer cells requires autophagy to maintain nutrient supply and intracellular hom......
The Distribution of Synaptotagmin Ⅱ in RBL-2H3 and Its Regulation on Exocytosis of Lysosomes in RBL-
Synaptotagmin (Syt) constitutes a family of membrane-trafficking proteins, so far nearly 20 Syts have been discovered. E......
Sorafenib is the first-line medication for advanced hepatocellular carcinoma(HCC),but it can only extend limited surviva......
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules,particles,and orga......
The presence of intraneuronal Lewy bodies(LBs)and Lewy neurites(LNs)in the substantia nigra(SN)composed of aggregatedα-......
炎症小体是一种由Nod样受体(NLR)家族成员与PYHIN(pyrin and HIN domain)家族成员组成的胞浆多蛋白复合物,能被多种病原相关分子模......
,Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cel
Aim: To evaluate the contribution of an autophagic mechanism to the As2O3-induced death of human acute myeloid leukaemia......
,CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neu
Increasing evidence suggests that Ras-related in brain 7 (Rab7),an endosome-localized small GTPase contributes to cerebr......
Lysosomes are the terminal organelles of the autophagic-endocytic pathway and play a key role in the degradation of auto......
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It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the l......
Autophagy is an intracellular degradation system that delivers cytoplasmic contents to the lysosome for degradation.It i......
,C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal
Lysosomes are degradation and signaling centers within the cell,and their dysfunction impairs a wide variety of cellular......
利用Suzuki偶联反应合成了疏水性寡聚芴分子OF,并对其在氯仿溶液中的紫外吸收和荧光光谱进行了表征,表明其具有较大的摩尔吸光系数......
细胞应对细菌或病毒感染及来自环境的各种化学药物时常表现为在细胞质内形成大量空泡，其中有些空泡来源于内体和溶酶体，称为内体和溶......
The Distribution of Synaptotagmin Ⅱ in RBL-2H3 and Its Regulation on Exocytosis of Lysosomes in RBL-
Synaptotagmin (Syt) constitutes a family of membrane-trafficking proteins, so far nearly 20 Syts have been discovered. E......
OBJECTIVE Identification of novel autophagy inhibitors for the combinational treatment of non-small cell lung cancer(NSC......
低效的溶酶体降解是多种脑部疾病发展的中心环节，但其具体机制及参与的细胞种类仍不清楚。既往研究显示，星形胶质细胞大量吞噬死亡的......
